Sunday, July 26, 2009

"Gender Puzzle" - What is a female? a male?



Here is the summary of the documentary "Gender Puzzle".

"Are we on the cusp of discovering what determines gender? The old mantra - all girls have XX chromosomes and all boys have XY - is no longer reliable. Scientists are now looking beyond chromosomes to "brain sex" and the role of newly discovered genes. By studying transsexuals and people on the gender extremes, they believe they can unlock the gender puzzle. This high-quality documentary looks at the new and challenging science of gender.



Tall, thin and strikingly beautiful, model Christie North always felt female. But when she was 15, she discovered she’d been born with male chromosomes. “There was no mention at school that there can be mix ups with your chromosomes”, she complains. “Many people have the same problem – more than you think.” As well as girls with XY chromosomes, one in 500 born with a double XX as well as a Y. Most only find out about their condition when they try to father children and discover they’re infertile. Until the 1990s, gender was largely about chromosomes. But this principle was challenged when a new gene was discovered which is needed to start the process of ‘maleness’. “I think we’re starting to understand how the brain is hard-wired differently between males and females”, explains Prof. Vince Harley. Scientists are now looking at a further 54 genes which are turned on differently in males and females. They may help to explain why people identify as one gender or the other, regardless of chromosomes. There is a small but growing body of evidence that transsexuals’ brains are hard-wired in the uterus to be either male or female. A Dutch study found that male-to-female transsexuals have the same brain features as other women instead of being identical to men’s. “There is a public perception that transsexualism is a lifestyle choice”, states Prof Vince Harley. “To reaffirm a biological basis is quite empowering for them.” These discoveries are starting to redefine the gender debate. In the 60s and 70s, it was believed the nature of a child’s upbring had such a strong influence that an intersex condition could be corrected through the right upbringing. The child was allocated a sex, underwent genital surgery and was then raised in its assigned sex. But many of these children had a traumatic childhood, unable to reconcile their identity with their bodies. For them, the ‘brain sex’ theory makes perfect sense. The theory of brain sex is also challenging the law. ‘Kevin’, a transsexual, was threatened with imprisonment if he married his female partner. He successfully contested this by providing the court with evidence suggesting a biological basis to his transsexualism. In his verdict, Justice Richard Chisolm concluded: “In view of all the evidence, the things that characterise transsexuals are as much biological as mental.” Far more controversial than adults changing gender, is the issue of teenagers who want to. “All the medical evidence indicates that the earlier children with transsexualism receive treatment, the better their lives are”, reasons lawyer and transsexual Rachel Wallbank. But others disagree. “You’re wondering all the time whether the young person actually has enough life experience to make that judgement”, states Craig Andrews. He runs a support group helping transsexuals and is concerned about the increasing number of young people who want treatment. As science discovers more about what determines gender, making these decisions may become a little easier. But for now, we are only just starting to understand just how complex the biology is."

And here is the complete transcript of this video.

See my PowerPoint slides for more information on intersexuality and transsexuality.

Friday, July 24, 2009

"Science and Sexuality" Presentation at Michigan Womyn's Music Festival


My presentation entitled "Science and Sexuality" will be given as a workshop at the National Womyn's Music Festival (aka MichFest) which runs from August 4th through the 9th in the woods near Walhalla, Michigan.
The evidence presented in my PowerPoint slides will be thoroughly discussed and additional information not in the slides will be woven into the talk. As always, questions and discussion will follow the presentation.

Here are the details:
Event: Workshop entitled "Science and Sexuality"
Day: Thursday, August 6th
Time: 3-5pm
Location: MichFest near Walhalla, Michigan
Site: Media Tent


MichFest is the first and the biggest of all women's music festivals and is attended by thousands of women from all over the United States who will coalesce in a tent city that pops up overnight in the woods of northern Michigan for the thirty-fourth year this August. As a largely lesbian event, this is a great venue for reaching a large number of women who already know the pains of being sexually different in a binary gender culture. If the MichFest audience receives the scientific information about intersex and transsexual persons as sympathetically as the audience at the National Women's Music Festival in Wisconsin did just a few weeks ago, then I will be very pleased.

Friday, July 10, 2009

Five Genders of Indonesia

Sex is biological. Gender is defined by culture. There are five genders in Indonesia. These Indonesian transsexuals seem comfortable with their somatic selves. Is this because the culture "welcomes" them and they are not forced to fit themselves into one of only two categories?

Tuesday, July 7, 2009

Sexual Development Determined “In Utero” By Two Independent Programs of Sex-Chromosomes and Androgen Influence


Below is the abstract of a hot new paper that elaborates on the "two layers" of sexual/gender programming that make you the "sexual somebody" you are at the time of birth. I will post more on this paper soon.

Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes
Paul-Martin Holterhus , Jan-Hendrik Bebermeier , Ralf Werner , Janos Demeter , Annette Richter-Unruh , Gunnar Cario , Mahesh Appari , Reiner Siebert , Felix Riepe , James D Brooks and Olaf Hiort
BMC Genomics 2009, 10:292doi:10.1186/1471-2164-10-292
Published: 1 July 2009

Abstract (provisional)

Background
Gender appears to be determined by independent programs controlled by the sex-chromosomes and by androgen-dependent programming during embryonic development. To enable experimental dissection of these components in the human, we performed genome-wide profiling of the transcriptomes of peripheral blood mononuclear cells (PBMC) in patients with rare defined "disorders of sex development" (DSD, e.g., 46,XY-females due to defective androgen biosynthesis) compared to normal 46,XY-males and 46,XX-females.

Results
A discrete set of transcripts was directly correlated with XY or XX genotypes in all individuals independent of male or female phenotype of the external genitalia. However, a significantly larger gene set in the PBMC only reflected the degree of external genital masculinization independent of the sex chromosomes and independent of concurrent post-natal sex steroid hormone levels. Consequently, the architecture of the transcriptional PBMC-"sexes" was either male, female or even "intersex" with a discordant alignment of the DSD individuals` genetic and hormonal sex signatures.

Conclusions
A significant fraction of gene expression differences between males and females in the human appears to have its roots in early embryogenesis and is not only caused by sex chromosomes but also by long-term sex-specific hormonal programming due to presence or absence of androgen during the time of external genital masculinization. Genetic sex and the androgen milieu during embryonic development might therefore independently modulate functional traits, phenotype and diseases associated with male or female gender as well as with DSD conditions.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Sunday, June 28, 2009

"Science and Sexuality" Presentation at National Women's Music Festival


My presentation “Science and Sexuality” will be given as a workshop at the 2009 National Women’s Music Festival. The Festival runs from July 2 through July 5th.

Event: "Science and Sexuality" presentation
Date: Saturday, July 4th
Time: 8:30 to 10:45 am
Location: Marriott Madison West Hotel in Middleton, WI
Room: Green Bay Room

The evidence presented in my PowerPoint slides will be thoroughly discussed and additional information not in the slides will be woven into the talk. There should be plenty of time afterward for questions and discussion. Please attend if you’re in the area.

See http://www.youtube.com/watch?v=3KsLEQ2EuR4 for a video from last year’s NWMF.

Saturday, June 27, 2009

Chaz Bono Was Never a Lesbian!


According to my interpretation of the scientific evidence (see PowerPoint slides), Chaz is a transman since he has a male (androcentric) identity). But since he is still gynephilic (attracted to women), Chaz is actually heterosexual. One must have a female identity to be a lesbian. Now that Chaz has come to grips with his “felt sexual identity,” the lesbian designation is automatically negated. The only change that’s happening is that Chaz’s gynemorphic body is now being altered to be more andromorphic.

Saturday, June 20, 2009

Same-Sex Behavior Found in Nearly All Animals


Seek and ye shall find! While many examples of homosexuality among animals have been documented in recent years, now biologists see homosexuality as widespread in the animal kingdom! Until recently, even some biologists were duped by the goofy Adam & Eve story so that they didn't see the homosexual behavior even when they were looking at it, and some were afraid to report the gay sex for fear of reprisals in such a homophobic culture. Now the cultural change that increasingly embraces diversity (started by the women's movement and furthered by gay and transgender activists) has affected science in a good way - opening the eyes of researchers and giving them the freedom to report what they find.

(It's ironic that while as a lesbian I have looked to science to help liberate me, I had never considered that advocacy for gay rights would liberate the scientists!)